Phosphotungstic Acid: An Efficient, Cost-effective and Recyclable Catalyst for the Synthesis of Polysubstituted Quinolines

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Phosphotungstic acid: an efficient, cost-effective and recyclable catalyst for the synthesis of polysubstituted quinolines.

Phosphotungstic acid (H(3)PW(12)O(40)) was used as an efficient and recyclable catalyst for the synthesis of polysubstituted quinolines through the Friedländer condensation of 2-aminoarylketone with carbonyl compounds, which was achieved by conventional heating under solvent-free conditions.

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Substituted 2, 4- diphenyl quinolines were synthesized by a multicomponent domino reaction of anilines, aldehydes and terminal aryl alkynes. The synthetic pathway involves the formation of an imine, followed by the intermolecular addition of an alkyne to the imine. This intermediate immediately undergoes ring closure and oxidative aromatization. The reaction is catalyzed by natural kaolin, a st...

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Natural kaolin as an efficient recyclable catalyst for the synthesis of new 2,4-disubstituted quinolines

Substituted 2, 4- diphenyl quinolines were synthesized by a multicomponent domino reaction of anilines, aldehydes and terminal aryl alkynes. The synthetic pathway involves the formation of an imine, followed by the intermolecular addition of an alkyne to the imine. This intermediate immediately undergoes ring closure and oxidative aromatization. The reaction is catalyzed by natural kaolin, a st...

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Melamine trisulfonic acid: An efficient and recyclable solid acid catalyst for the green synthesis of Biscoumarin derivatives

A novel catalytic synthesis of 3,3'-(arylmethylene)-bis-(4-hydroxy-2H-chromene-2-one) derivatives from a tandem condensation reaction of 4-hydroxycoumarin and aromatic aldehydes has been developed. The reaction occurs in water in the presence of Melamine trisulfonic acid as catalyst to give the corresponding products in good to high yields. This green approach has several advantages such as sho...

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ژورنال

عنوان ژورنال: Molecules

سال: 2009

ISSN: 1420-3049

DOI: 10.3390/molecules14031126